Computational investigation of novel synthetic analogs of C-1′β substituted remdesivir against
RNA-dependent RNA-polymerase of SARS-CoV-2
Savio Cardozaa
∙ Anirudh Singhb
∙ Souvik Surc
∙ Mintu Singha
∙ Kshatresh D. Dubeyd
∙ Sintu
Kumar Samantab
∙ Ajay Mandale
∙ Vibha Tandona,f
https://doi.org/10.1016/j.heliyon.2024.e36786
Heliyon 10 (2024) e36786
Multistep Synthesis of Analogues of Remdesivir: Incorporating
Heterocycles at the C‑1′ Position
Savio Cardoza, Manoj Kumar Shrivash, Laura Riva, Arnab K. Chatterjee, Ajay Mandal,*
and Vibha Tandon*
https://doi.org/10.1021/acs.joc.3c00754
J. Org. Chem. 2023, 88, 13, 9105–9122
Ghosh, N., & Kundu, L. M. (2023). Cyclic di-peptide in situ inhibited proteinaggregation. Bioorganic & medicinal chemistry letters, 91, 129379.
https://doi.org/10.1016/j.bmcl.2023.129379
Ghosh, N., & Kundu, L. M. (2021). In-situ side-chain peptide cyclization as a breaker strategy
against the amyloid aggregating peptide. Bioorganic & medicinal chemistry, 33, 116017.
https://doi.org/10.1016/j.bmc.2021.116017
Ghosh, N., & Kundu, L. M. (2021). Breaker Peptides Against amyloid-β Aggregation: a
Potential Therapeutic Strategy for Alzheimer’s Disease. Future Medicinal Chemistry, 13(20),
1767–1794. https://doi.org/10.4155/fmc-2021-0184
Isotope Effects on the Enzymatic and Non-Enzymatic Reactions of Chorismate, Wright, K. S;
Declue M.; Mandal, A; Lee, L; Wiest, O; Cleland, W. W.; Hilvert, D., J. Am. Chem. Soc. 2005,
127, 12957-12964.
Stereocontrol in organic synthesis using Silicon-containing compounds. Studies directed
towards the synthesis of ebelactone-a, Archibald, S. C.; Barden, D. J.; Bazin, J. F. Y.;
Fleming, I.; Foster, C.; Mandal, A. K.; Mandal, A. K.; Parker, D.; Tekaki, K.; Ware, A. C.;
Williams, A. R. B.; Zwicky, A. B., Org. Biomole. Chem., 2004, 2, 1051-1064.
Charge Optimization Increases the Potency and Selectivity of a Chorismate Mutase Inhibitor,
Mandal, A.; Hilvert, D., J. Am. Chem. Soc. 2003, 125, 5598-5599.
Trapping the tetrahedral intermediate in the 1,3-shift of an acetyl group using a triisopropylsilyl
group, Fleming, I.; Mandal, A. K., J. Indian Chemical Society, 2000, 77, 579-584.
Stereocontrol in organic synthesis using silicon compounds—Ebelactone-a, Fleming, I.;
Mandal, A. K.; Mandal, A. K., conference proceedings of the 8th International Symposium on
Natural Product Chemistry, Karachi, 2000.
Unusual cyclopropanol formation from a -silyl aldehyde, Fleming, I.; Mandal, A. K. J. Chem.
Soc., Chem. Commun., 1999, 923.
A versatile aerobic oxidation of organic compounds catalyzed by Cobalt (II) porphyrins
Mandal A. K., Iqbal J. Tetrahedron, 1997, 53, 7641.
Cobalt catalyzed organic transformations: Highly versatile protocols for carbon-carbon and
carbon-heteroatom bond formation, Iqbal J., Mukhopadhyay M., Mandal A. K. SYN LETT,
1997, 8, 876.
Cobalt (II) porphyrin: A versatile catalyst for the oxidation of organic substrates with dioxygen
and 2-methyl propanal, Mandal A. K., Khanna V., Iqbal J. Tetrahedron Lett., 1996, 37, 3769.
Patents
PAUL, Rebecca; RACKHAM, Mark; MOK, Yi; VASS, Marton; MEYERS, Joshua; CRONIN,
Andrew; MANDAL, Ajay; WO2020/260871Al; WO2020/039290A1; WO2020/016594A1
Paul R, Mandal, A. et al, GB1909036.4 & GB1913565.6
Zhaoning Zhu, Mandal, A., et al. (PCT/EP2016/062900) WO2016/198400 A1
Zhaoning Zhu, Mandal, A., US2018134728 (A1)
Showell, G., Miller, D., Mandal, A., Tacke, R., Daiss, J., (PCT/GB2004/001781) WO
2004/094436
Showell, G., Walsh, L., Mandal, A., (PCT/GB2004/001781) WO 2006/064277
Showell, G., Miller, D., Glen, A., Cubillo de dios, M.A., Merchant, K., Mandal, A.,
PCT/GB2006/002344, WO 2007/000582
Showell, G., Miller, D., Mandal, A., PCT/GB2005/PP192
Showell, G., Miller, D., Mandal, A., PCT/GB2005/PP192
Showell, G., Miller, D., Mandal, A., PCT/GB2004/0206
Showell, G., Miller, D., Mandal, A., PCT/GB2006/PTD634 selection patent